colon (plural colons or cola or coli) (anatomy) Part of the large intestine; the final segment of the digestive system, after (distal to) the ileum and before (proximal to) the rectum.
cancer that forms in the tissues of the colon (the longest part of the large intestine). most colon cancers are adenocarcinomas (cancers that begin in cells that make and release mucus and other fluids).