A team of researchers has generated one of the most detailed 3D maps of human chromosomes, cataloging over 140,000 DNA looping interactions.

The researchers focused on the structure and dynamics of kinetoplast DNA, the mitochondrial genome of Trypanosomes, with an experimental study led by Edinburgh and a computational analysis that ...

Inside cells, DNA twists and coils itself into a variety of different secondary structures—including i-motifs (iMs) and G-quadruplexes (G4s)—that influence gene expression. Some drugs target these ...

After 10 years, members of the 4D Nucleome consortium have successfully completed the first phase of a project that aims to ...

CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.