Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Metal-mediated base pairing in nucleic acids represents a transformative approach wherein traditional Watson–Crick hydrogen bonds are replaced or supplemented by coordinate bonds with metal ions. This ...

Structural comparison of DNA and the artificial TNA, a Xeno nucleic acid with the natural base pairs AT and GC and an additional base pair (XY). The DNA carries the genetic information of all living ...

Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases. (Image: Wikimedia Commons, CC SA 3.0) The most common type of base pairing is the Watson-Crick base ...

A researcher is developing a patent-pending platform technology called LENN that mimics the dual-layer structure of viruses to deliver nucleic acid (NA)-based therapies to targeted cancer cells. A ...

Inside cells, DNA twists and coils itself into a variety of different secondary structures—including i-motifs (iMs) and G-quadruplexes (G4s)—that influence gene expression. Some drugs target these ...

Synthetic nucleic acid analogues are known as xeno nucleic acids (XNAs), which is appropriate because “xeno” means “alien” or “strange.” To date, most XNAs have been just a little strange, containing ...

For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory. The DNA carries the genetic information of all ...